Sertraline enhances the activity of antimicrobial agents against pathogens of clinical relevance

Table 1 Antibacterial effect of antibiotics alone and in combination with sertraline (SR) against S. aureus 6538

Diameter of the inhibitory zone (mm) Mean ± SEM (n = 5)
Antibiotic	Control	Antibiotic + SR 10 μ g ml ⁻¹	Antibiotic + SR 20 μg ml ⁻¹	Antibiotic + SR 40 μg ml ⁻¹	Antibiotic + SR 60 μg ml ⁻¹	Antibiotic + SR 80 μg ml ⁻¹	Antibiotic + SR 100 μg ml ⁻¹
Ciprofloxacin 5 μg	21.50 ± 0.70	22.25 ± 0.50	24 ± 1.41	29 ± 1.40	30 ± 4.24*	37 ± 2.82**	39.5 ± 2.12**
Levofloxacin 5 μg	20.50 ± 0.70	21.70 ± 0.00	23 ± 1.41	25.50 ± 0.70	26.50 ± 0.70	33 ± 5.65*	36.5 ± 4.94**
Norfloxacin 10 μg	16.50 ± 0.70	17.5 ± 0.50	20.50 ± 2.12	21 ± 1.41	24 ± 1.41	34.5 ± 7.77*	36.5 ± 7.77*
Moxifloxacin 5 μg	22 ± 1.41	22 ± 0.00	23 ± 1.41	26.50 ± 0.70	28.50 ± 0.70	34.50 ± 4.94*	37.5 ± 3.53**
Cefexime 5 μg	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00
Cloxacillin 5 μg	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00
Gentamicin10 μg	21.50 ± 0.70	22.50 ± 0.20	24.5 ± 0.70	27.50 ± 0.70**	29 ± 1.41**	35 ± 1.41***	36.5 ± 0.7***

Significantly different as compared to antibiotic treated group only: *p < 0.05, **p < 0.01, ***p < 0.001. Each value represent the mean of five replicates (n = 5). Control: Antibiotic treated group only.

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