Sertraline enhances the activity of antimicrobial agents against pathogens of clinical relevance

Table 3 Antibacterial effect of sertraline (SR) and antibiotics combination against P. aeruginosa 9027

Diameter of the inhibitory zone (mm) Mean ± SEM (n = 5)
Antibiotic	Control	Antibiotic + SR 10 μg ml ⁻¹	Antibiotic + SR 20 μg ml ⁻¹	Antibiotic + SR 40 μg ml ⁻¹	Antibiotic + SR 60 μg ml ⁻¹	Antibiotic + SR 80 μg ml ⁻¹	Antibiotic + SR 100 μg ml ⁻¹
Ciprofloxacin 5 μg	20 ± 0.00	20.8 ± 0.20	22 ± 2.82	26 ± 2.82	29 ± 2.82*	33 ± 2.82**	40 ± 2.82***
Levofloxacin 5 μg	22 ± 1.41	23.0 ± 0.50	24 ± 1.41	27 ± 1.41*	30 ± 1.41**	37 ± 1.41***	41 ± 0.00***
Norfloxacin 10 μg	20 ± 0.00	21 ± 0.70	24.5 ± 0.70**	26.50 ± 0.70***	30.50 ± 0.70***	33.5 ± 0.70***	39.5 ± 0.70***
Moxifloxacin 5 μg	24 ± 1.41	24 ± 0.50	26 ± 1.41	28 ± 1.41	32 ± 1.41**	36 ± 1.41***	42.5 ± 0.70***
Cefexime 5 μg	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00
Cloxacillin 5 μg	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00
Gentamicin 10 μg	24.50 ± 70	25 ± 0.50	26.50 ± 0.70	29.50 ± 0.70*	33.50 ± 0.70***	38.50 ± 0.70***	41.5 ± 0.70***

Values significantly different as compare to antibiotic treated group only: *p < 0.05, **p < 0.01, ***p < 0.001. Control: Antibiotic treated group only.

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