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Table 2 Long QT syndrome as a causative factor of SIDS and implicated mutations—Genetic studies focusing on one single or two genes

From: Sudden infant death syndrome due to long QT syndrome: a brief review of the genetic substrate and prevalence

Study/year

Study type

Total number of cases

Number of SIDS cases with causative mutation

Genes

Mutations

Kato et al./2014 [23]

Case–control

7

4

SCN5A

p.N1774D, p.F1486del, p.N406K

KCNH2

p.G628D

Tan et al./2010 [24]

Case–control

292

1 (0.3%)

SCN4B

p.S206L*

Cheng et al./2009 [25]

Case–control

292

3 (1%)

SNTA1

p.S287R, p.T372M, p.G460S

Cronk et al./2007 [26]

Case–control

134

3 (2.2%)

CAV3

p.V14L, p.T78M, p.L79R

Plant et al./2006 [27]

Case–control

133

7 (5.2%)

SCN5A

p.S1103Y, p.S524Y, p.R689H, p.E1107K

Lupoglazoff et al./2004 [28]

Case–control

23

3 (13%)

KCNH2

p.G604S

Ackerman et al./2001 [29]

Case–control

93

2 (2.1%)

SCN5A

p.A997S, p.R1826H

  1. * Sequence variation is previously unreported and is of the type which may or may not be causative of the disorder