Sudden infant death syndrome due to long QT syndrome: a brief review of the genetic substrate and prevalence

Table 2 Long QT syndrome as a causative factor of SIDS and implicated mutations—Genetic studies focusing on one single or two genes

Study/year	Study type	Total number of cases	Number of SIDS cases with causative mutation	Genes	Mutations
Kato et al./2014 [23]	Case–control	7	4	SCN5A	p.N1774D, p.F1486del, p.N406K
Kato et al./2014 [23]	Case–control	7	4	KCNH2	p.G628D
Tan et al./2010 [24]	Case–control	292	1 (0.3%)	SCN4B	p.S206L*
Cheng et al./2009 [25]	Case–control	292	3 (1%)	SNTA1	p.S287R, p.T372M, p.G460S
Cronk et al./2007 [26]	Case–control	134	3 (2.2%)	CAV3	p.V14L, p.T78M, p.L79R
Plant et al./2006 [27]	Case–control	133	7 (5.2%)	SCN5A	p.S1103Y, p.S524Y, p.R689H, p.E1107K
Lupoglazoff et al./2004 [28]	Case–control	23	3 (13%)	KCNH2	p.G604S
Ackerman et al./2001 [29]	Case–control	93	2 (2.1%)	SCN5A	p.A997S, p.R1826H

* Sequence variation is previously unreported and is of the type which may or may not be causative of the disorder

ISSN: 2241-5793