Fig. 1

HIV receptor integrated hematopoietic stem cell formation. Hematopoietic stem cells can be collected from healthy person having O-negative (O^−/−) blood group. HIV receptor-CD4 and co-receptors-CCR5 and CXCR4 will then be transgenically introduced onto the hematopoietic stem cell membranes by stably transducing or transfecting HSC with receptor genes under GATA-1 promoter control to form riHSC using viral or non-viral vectors. These receptor positive stem cells will be sorted using HIV receptors for next treatment. HIV human immunodeficiency virus, HSC hematopoietic stem cell, CD4 cluster of differentiation 4, CCR5 C-C chemokine receptor type 5, CXCR4 C-X-C chemokine receptor type 4, riHSC receptor-integrated hematopoietic stem cell