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Fig. 4 | Journal of Biological Research-Thessaloniki

Fig. 4

From: Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy

Fig. 4

Trapping HIVs within riRBC and destroying them. Once in blood, the riRBCs will engage to bind free HIV particles by the interaction of viral glycoproteins gp 120 and gp 41 with its membrane embedded CD4, CCR5 and CXCR4. After attachment fusion of viral and riRBC membrane will result in uncoating of viral core contents within cell cytoplasm leading to reverse transcription using its own transcriptase to form PIC. A single riRBC will be able to trap numerous HIV-PIC. However, once PIC formed it will remain inert as it will hardly find any genome to integrate and finally will be destroyed along with aged riRBC in spleen. HIVs human immunodeficiency viruses, CD4 cluster of differentiation 4, CCR5 C-C chemokine receptor type 5, riRBC receptor integrated red blood corpuscle, PIC pre integration complex

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