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Table 1 Induction of apoptosis and micronucleation in HL-60 cells after treatment with doxorubicin

From: Combined study on clastogenic, aneugenic and apoptotic properties of doxorubicin in human cells in vitro

Doxorubicin (μg ml−1) Induction of apoptosis Total cells Micronucleus Induction
Total cells Live cells (%)
Mean ± SE
Apoptotic cells (%)
Mean ± SE
Cells with MN (%)
Mean ± SE
CBPI Cytotoxicity (%)
Mean ± SE
0 9262 8507
92.43 ± 2.55
748
7.5 ± 2.51
5122 55
1.1 ± 0.19
1.55 ± 0.07
0.5 10,614 4260
39.83 ± 4.48
6220
58.88* ± 4.35
2329 47
3.86* ± 1.87
1.22 ± 0.03 60.01 ± 3.35
2 10,673 1417
12.95 ± 2.81
8587
80.51* ± 0.56
483 8
1.3 ± 0.39
1.28 ± 0.07 50.61 ± 9.77
  1. MN micronucleus, CPBI Cytokinesis Block Proliferation Index, SE standard error
  2. * p ≤ 0.0001 in comparison with control (G-test)