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Table 1 Induction of apoptosis and micronucleation in HL-60 cells after treatment with doxorubicin

From: Combined study on clastogenic, aneugenic and apoptotic properties of doxorubicin in human cells in vitro

Doxorubicin (μg ml−1)

Induction of apoptosis

Total cells

Micronucleus Induction

Total cells

Live cells (%)

Mean ± SE

Apoptotic cells (%)

Mean ± SE

Cells with MN (%)

Mean ± SE

CBPI

Cytotoxicity (%)

Mean ± SE

0

9262

8507

92.43 ± 2.55

748

7.5 ± 2.51

5122

55

1.1 ± 0.19

1.55 ± 0.07

0.5

10,614

4260

39.83 ± 4.48

6220

58.88* ± 4.35

2329

47

3.86* ± 1.87

1.22 ± 0.03

60.01 ± 3.35

2

10,673

1417

12.95 ± 2.81

8587

80.51* ± 0.56

483

8

1.3 ± 0.39

1.28 ± 0.07

50.61 ± 9.77

  1. MN micronucleus, CPBI Cytokinesis Block Proliferation Index, SE standard error
  2. * p ≤ 0.0001 in comparison with control (G-test)