Fig. 1From: The decreased SIRT1 level may account for the lipid profile in chronic kidney diseaseThe key pathways and target genes of the SIRT1 concerning cholesterol, fatty acids, bile acid, and triglyceride homeostasis. Decreased SIRT1 eventually promotes triglyceride, fatty acid, and cholesterol synthesis, whereas represses fatty acid beta-oxidation. As a result, the lipid profiles alter due to the SIRT1 levelBack to article page