Table 3 Univariate and multivariate Cox Regression analysis of tumor samples in the training set and validation set

Training set

 Age (years, mean ± SD)

1.026 [1.006–1.047]

9.392 × 10⁻³

1.016 [1.011–1.430]

2.034 × 10⁻²

 Gender (male/female)

0.996 [0.625–1.588]

9.867 × 10⁻¹

–

–

 Pathologic M (M0/M1/–)

1.525 [0.544–4.278]

4.180 × 10⁻¹

–

–

 Pathologic N (N0/N1/N2/N3/–)

1.611 [1.289–2.013]

1.615 × 10⁻⁵

0.999 [0.593–1.684]

6.340 × 10⁻¹

 Pathologic T (T1/T2/T3/T4/–)

1.594 [1.175–2.163]

2.619 × 10⁻³

0.858 [0.486–1.516]

9.980 × 10⁻¹

 Pathologic stage (I/II/III/IV/–)

1.661 [1.288–2.142]

6.357 × 10⁻⁵

1.498 [0.926–2.424]

3.970 × 10⁻¹

 Pathologic grade (High/low/–)

3.164 [0.439–22.77]

2.27 × 10⁻¹

–

–

 Radiotherapy (yes/no/–)

0.948 [0.233–3.863]

9.402 × 10⁻¹

–

–

 Lymphovascular invasion (yes/no/–)

2.411 [1.441–4.034]

5.576 × 10⁻⁴

1.709 [0.893–3.274]

1.050 × 10⁻²

 Recurrence (yes/no)

1.621 [0.986–2.667]

5.473 × 10⁻²

–

–

 MiR score (high/low)

3.926 [2.500–6.165]

1.905 × 10⁻¹⁰

3.431 [1.919–6.130]

3.180 × 10⁻⁵

Validation set

 Age (years, mean ± SD)

1.038 [1.013–1.064]

2.272 × 10⁻³

1.069 [1.0262–1.113]

1.340 × 10⁻³

 Gender (male/female)

1.275 [0.808–2.011]

2.955 × 10⁻¹

–

–

 Pathologic M (M0/M1/–)

23.27 [6.683–81.03]

5.850 × 10⁻¹

–

–

 Pathologic N (N0/N1/N2/N3/–)

1.564 [1.231–1.987]

1.749 × 10⁻³

1.652 [0.854–3.195]

1.359E−01

 Pathologic T (T1/T2/T3/T4/–)

1.985 [1.421–2.773]

5.099 × 10⁻⁵

1.858 [0.937–3.690]

7.634 × 10⁻²

 Pathologic stage (I/II/III/IV/–)

1.836 [1.374–2.453]

2.048 × 10⁻⁵

0.668 [0.276–1.617]

3.710 × 10⁻¹

 Pathologic grade (high/low/–)

2.637 [0.365–19.07]

3.180 × 10⁻¹

–

–

 Radiotherapy (yes/no/–)

1.188 [0.516–2.736]

6.850 × 10⁻¹

–

–

 Lymphovascular invasion (yes/no/–)

2.335 [1.338–4.074]

2.119 × 10⁻³

1.338 [1.056–3.177]

4.509 × 10⁻²

 Recurrence (yes/no)

2.023 [1.171–3.495]

1.002 × 10⁻²

1.002 [0.468–2.144]

9.960 × 10⁻¹

 MiR score (high/low)

1.772 [1.148–2.734]

8.821 × 10⁻³

2.353 [1.0702–5.176]

3.328 × 10⁻²