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Table 3 Univariate and multivariate Cox Regression analysis of tumor samples in the training set and validation set

From: A potential prognostic model based on miRNA expression profile in The Cancer Genome Atlas for bladder cancer patients

Clinical characteristics Uni-Cox regression Multi-Cox regression
HR [95% CI] p-value HR [95% CI] p-value
Training set
 Age (years, mean ± SD) 1.026 [1.006–1.047] 9.392 × 10−3 1.016 [1.011–1.430] 2.034 × 10−2
 Gender (male/female) 0.996 [0.625–1.588] 9.867 × 10−1
 Pathologic M (M0/M1/–) 1.525 [0.544–4.278] 4.180 × 10−1
 Pathologic N (N0/N1/N2/N3/–) 1.611 [1.289–2.013] 1.615 × 10−5 0.999 [0.593–1.684] 6.340 × 10−1
 Pathologic T (T1/T2/T3/T4/–) 1.594 [1.175–2.163] 2.619 × 10−3 0.858 [0.486–1.516] 9.980 × 10−1
 Pathologic stage (I/II/III/IV/–) 1.661 [1.288–2.142] 6.357 × 10−5 1.498 [0.926–2.424] 3.970 × 10−1
 Pathologic grade (High/low/–) 3.164 [0.439–22.77] 2.27 × 10−1
 Radiotherapy (yes/no/–) 0.948 [0.233–3.863] 9.402 × 10−1
 Lymphovascular invasion (yes/no/–) 2.411 [1.441–4.034] 5.576 × 10−4 1.709 [0.893–3.274] 1.050 × 10−2
 Recurrence (yes/no) 1.621 [0.986–2.667] 5.473 × 10−2
 MiR score (high/low) 3.926 [2.500–6.165] 1.905 × 10−10 3.431 [1.919–6.130] 3.180 × 10−5
Validation set
 Age (years, mean ± SD) 1.038 [1.013–1.064] 2.272 × 10−3 1.069 [1.0262–1.113] 1.340 × 10−3
 Gender (male/female) 1.275 [0.808–2.011] 2.955 × 10−1
 Pathologic M (M0/M1/–) 23.27 [6.683–81.03] 5.850 × 10−1
 Pathologic N (N0/N1/N2/N3/–) 1.564 [1.231–1.987] 1.749 × 10−3 1.652 [0.854–3.195] 1.359E−01
 Pathologic T (T1/T2/T3/T4/–) 1.985 [1.421–2.773] 5.099 × 10−5 1.858 [0.937–3.690] 7.634 × 10−2
 Pathologic stage (I/II/III/IV/–) 1.836 [1.374–2.453] 2.048 × 10−5 0.668 [0.276–1.617] 3.710 × 10−1
 Pathologic grade (high/low/–) 2.637 [0.365–19.07] 3.180 × 10−1
 Radiotherapy (yes/no/–) 1.188 [0.516–2.736] 6.850 × 10−1
 Lymphovascular invasion (yes/no/–) 2.335 [1.338–4.074] 2.119 × 10−3 1.338 [1.056–3.177] 4.509 × 10−2
 Recurrence (yes/no) 2.023 [1.171–3.495] 1.002 × 10−2 1.002 [0.468–2.144] 9.960 × 10−1
 MiR score (high/low) 1.772 [1.148–2.734] 8.821 × 10−3 2.353 [1.0702–5.176] 3.328 × 10−2
  1. Italic values indicate p value < 0.05
  2. M distant metastases, N regional lymph node, T tumor size, HR hazard ratio