Table 4 GO and KEGG enrichment analyses of DEGs
Category | Term | Count | p-value | Genes |
|---|---|---|---|---|
Biology process | GO:0006811 ~ ion transport | 41 | 5.51 × 10−8 | SLC8A3, SLC36A2, GABRB3 |
GO:0016337 ~ cell–cell adhesion | 21 | 1.15 × 10−6 | HCN4, SLC4A4, CAMK2A, | |
GO:0050877 ~ neurological system process | 50 | 3.23 × 10−6 | IGDCC3, OR10A3, GABRB3 | |
GO:0030001 ~ metal ion transport | 27 | 3.97 × 10−6 | CPLX3, DRD2, OPRK1 | |
GO:0007267 ~ cell–cell signaling | 31 | 6.68 × 10−6 | LIN7A, SFRP5, PENK | |
GO:0006812 ~ cation transport | 29 | 1.09 × 10−5 | SLC8A3, SLC36A2, DRD2 | |
GO:0019226 ~ transmission of nerve impulse | 22 | 1.21 × 10−5 | SLC24A5, CACNG4, KCNK2 | |
GO:0030182 ~ neuron differentiation | 25 | 1.34 × 10−5 | TUBB2B, RTN4RL1, PTPRZ1 | |
GO:0007268 ~ synaptic transmission | 20 | 1.37 × 10−5 | CPLX3, PLP1 | |
GO:0006936 ~ muscle contraction | 14 | 1.69 × 10−5 | ACTC1, MYBPC2, DRD2 | |
GO:0048667 ~ cell morphogenesis involved in neuron differentiation | 16 | 2.87 × 10−5 | RTN4RL1, DRD2, PTPRZ1 | |
KEGG pathway | hsa04080:Neuroactive ligand-receptor interaction | 16 | 2.10 × 10−4 | GPR156, CALCR, GABRB3 |
hsa04020:Calcium signaling pathway | 12 | 9.18 × 10−4 | SLC8A3, ATP2B2, ADRB3 | |
hsa04514:Cell adhesion molecules (CAMs) | 9 | 0.00562107 | NCAM1, NCAM2, CADM3 | |
hsa04540:Gap junction | 6 | 0.036085973 | ADCY2, TUBB2B, DRD2 |