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Fig. 6 | Journal of Biological Research-Thessaloniki

Fig. 6

From: Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment

Fig. 6

In vivo therapeutic efficacy of 4-PMPB, 4-EMPB and 4-MMPB on immunocompromised C57BL/6 mice bearing PC-3 tumors. a Representative image of tumors at day 15 after various treatments. b Tumor growth curves indicated, cisplatin and high doses of 4-PMPB, 4-EMPB and 4-MMPB had remarkable anti-tumor effects during the 15 days of treatments. c At the end of the experiment, tumor volumes were measured and significant differences were observed between the PBS and HCl controls and those treated with 50 mg kg-1 of the compounds as well as cisplatin groups. d The body weights of different groups were continuously evaluated during the 15 days follow up. e There was a significant difference in body weight loss between cisplatin and other treatment groups on day 15. Data are expressed as mean ± SD, n = 8. ** p < 0.01, *** p < 0.001 and **** p < 0.0001

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