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Table 2 Anti-proliferative activity of tested compounds on PC-3 and HDF cells during 24, 48, and 72 h of treatments

From: Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment

Compounds

IC50 (µM) ± SD (PC-3)

IC50 (µM) ± SD (HDF)

24 h

48 h

72 h

24 h

48 h

72 h

4-PMPB

122.303 ± 2.618

88.45 ± 2.312

57.58 ± 2.123

1641.10 ± 0.075

1443.73 ± 0.055

1028.86 ± 0.139

4-EMPB

107.44 ± 6.17

74.95 ± 3.39

48.99 ± 6.76

545.55 ± 1.99

361.70 ± 2.29

258.87 ± 1.86

4-MMPB

100.76 ± 2.412

55.55 ± 1.980

40.79 ± 1.795

331.42 ± 3.332

284.09 ± 2.975

185.61 ± 2.805

Cisplatin

62.29 ± 1.741

51.53 ± 1.425

41.63 ± 1.108

153.42 ± 2.89

119.49 ± 2.565

71.09 ± 3.337

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Journal of Biological Research-Thessaloniki

ISSN: 2241-5793

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