Predicted antiviral drugs Darunavir, Amprenavir, Rimantadine and Saquinavir can potentially bind to neutralize SARS-CoV-2 conserved proteins

Table 12 Comparison of drug binding motifs of analyzed NSPs for antiviral drugs

	7K3N (Nsp1)	6WEY (Nsp3)	6M03 (Nsp5)	7JLTNsp7-8	6W4B (Nsp9)	6ZCTNsp10	6M71 (Nsp7/8/12)	7NIO Nsp13	5C8S (Nsp14)	6VWW (Nsp15)	7BQ7 Nsp16-10	Total binding sites
Amphetamine			+									1
Amprenavir	+ + +	+ + + +		+ +			+ + +	+ + +	+ + +	+ +	+ +	22
Atazanavir	+					+ +	+	+	+	+	+ + +	10
Darunavir	+ + + + + + + + + +	+ + + + + +	+ +	+		+ + +	+ + + +	+ +	+ + + + + + +	+ + + + +	+ + + + +	45
Grazoprevir					+	+ +			+		+ +	6
Indinavir	+		+			+	+	+ + +	+	+ + +	+	12
Lopinavir						+		+ +	+ +	+ + +	+	9
Nelfinavir	+ +		+	+			+ +	+			+	8
Nevirapine			+									1
Ribavirin			+		+							2
Rimantadine	+	+ +	+ + +	+	+ + +		+	+ +	+ + + + +		+ +	20
Ritonavir			+			+		+			+ +	5
Saquinavir	+ +	+		+		+	+ + +	+	+ +	+ + +	+ + + +	18
Tipranavir	+	+ +	+		+		+ +	+	+ +	+	+	12

Among fourteen drugs four (Amprenavir, Darunavir, Rimantadine, Saquinavir) have very significant and the other two (Indinavir, Tipranavir) have moderatenumber of binding motifs. ‘ + ’ sign indicates no. of drug binding motifs

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