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Table 5 Possible binding sites of NSP9 against known anti-viral drugs

From: Predicted antiviral drugs Darunavir, Amprenavir, Rimantadine and Saquinavir can potentially bind to neutralize SARS-CoV-2 conserved proteins

Drugs   Total binding sites    (6W4B) NSP9 Replicase of COVID-19
Grazoprevir Known similar target molecule NS3 protease, NS4a protein,
Hepacivirus C
Binding properties 1 1 Superposition type L
RMSD 0.94 Å
Amino acid targets of drug 66 ILE
59 LYS
62 GLY
No. of residues in known binding 16
Human similar targets 8
Ribavirin Known similar target molecule RNA polymerase,
Norwalk virus
Binding properties 1 1 Superposition type R
RMSD 0.80 Å
Amino acid targets of drug 36 THR
35 THR
34 ASN
No. of residues in known binding 09
Human similar targets 2
Rimantadine Known similar target molecule M2, BM2 protein,
Influenza A,B
Binding properties 3 1 Superposition type L
RMSD 0.90 Å
Amino acid targets of drug 109 ALA
106 SER
105 GLY
No. of residues in known binding 9
Human similar targets 0
2 Superposition type R
RMSD 1.10 Å
Amino acid targets of drug 111 VAL
108 VAL
106 SER
No. of residues in known binding 10
Human similar targets 0
3 Superposition type R
RMSD 1.26 Å
Amino acid targets of drug 111 VAL
109 ALA
106 SER
No. of residues in known binding 10
Human similar targets 0
Tipranavir Known similar target molecule Protease, HIV-1
Binding properties 1 1 Superposition type L
RMSD 1.21 Å
Amino acid targets of drug 16 ALA
26 ASP
27 ASP
No. of residues in known binding 27
Human similar targets 3
  1. Features of different drug binding motifs. HIV-1 Human Immunodeficiency virus 1, RMSD Root Mean Square Deviation, Å angstrom, ILE isoleucine, GLY glycine, VAL valine, ASP aspartic acid, ASN asparagine, ALA alanine, THR threonine, LYS lysine, SER serine