Drugs | Â | Total binding sites | Â | Â | (6W4B) NSP9 Replicase of COVID-19 |
---|---|---|---|---|---|
Grazoprevir | Known similar target molecule | NS3 protease, NS4a protein, Hepacivirus C | |||
Binding properties | 1 | 1 | Superposition type | L | |
RMSD | 0.94Â Ã… | ||||
Amino acid targets of drug | 66 ILE 59 LYS 62 GLY | ||||
No. of residues in known binding | 16 | ||||
Human similar targets | 8 | ||||
Ribavirin | Known similar target molecule | RNA polymerase, Norwalk virus | |||
Binding properties | 1 | 1 | Superposition type | R | |
RMSD | 0.80Â Ã… | ||||
Amino acid targets of drug | 36 THR 35 THR 34 ASN | ||||
No. of residues in known binding | 09 | ||||
Human similar targets | 2 | ||||
Rimantadine | Known similar target molecule | M2, BM2 protein, Influenza A,B | |||
Binding properties | 3 | 1 | Superposition type | L | |
RMSD | 0.90Â Ã… | ||||
Amino acid targets of drug | 109 ALA 106 SER 105 GLY | ||||
No. of residues in known binding | 9 | ||||
Human similar targets | 0 | ||||
2 | Superposition type | R | |||
RMSD | 1.10Â Ã… | ||||
Amino acid targets of drug | 111 VAL 108 VAL 106 SER | ||||
No. of residues in known binding | 10 | ||||
Human similar targets | 0 | ||||
3 | Superposition type | R | |||
RMSD | 1.26Â Ã… | ||||
Amino acid targets of drug | 111 VAL 109 ALA 106 SER | ||||
No. of residues in known binding | 10 | ||||
Human similar targets | 0 | ||||
Tipranavir | Known similar target molecule | Protease, HIV-1 | |||
Binding properties | 1 | 1 | Superposition type | L | |
RMSD | 1.21Â Ã… | ||||
Amino acid targets of drug | 16 ALA 26 ASP 27 ASP | ||||
No. of residues in known binding | 27 | ||||
Human similar targets | 3 |