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Table 6 Possible binding sites of NSP10 against known anti-viral drugs

From: Predicted antiviral drugs Darunavir, Amprenavir, Rimantadine and Saquinavir can potentially bind to neutralize SARS-CoV-2 conserved proteins

Drugs   Total binding sites    (6ZCT) NSP10 of COVID-19
Atazanavir Known similar target molecule Protease, HIV-1
Binding properties 2 1 Superposition type R
RMSD 0.94 Å
Amino acid targets of drug 107 PRO
108 VAL
38 ILE
No. of residues in known binding 19
Human similar targets 4
2 Superposition type L
RMSD 1.01 Å
Amino acid targets of drug 78 ARG
107 PRO
108 VAL
No. of residues in known binding 23
Human similar targets 3
Darunavir Known similar target molecule Protease, HIV-1
Binding properties 3 1 Superposition type R
RMSD 0.99 Å
Amino acid targets of drug 78 ARG
107 PRO
108 VAL
No. of residues in known binding 26
Human similar targets 7
2 Superposition type L
RMSD 1.09 Å
Amino acid targets of drug 78 ARG
37 PRO
38 ILE
No. of residues in known binding 22
Human similar targets 6
3 Superposition type L
RMSD 0.85 Å
Amino acid targets of drug 26 ALA
22 ASP
21 VAL
No. of residues in known binding 27
Human similar targets 8
Grazoprevir Known similar target molecule NS3, NS4 Protease, Hepacivirus C
Binding properties 2 1 Superposition type L
RMSD 0.76 Å
Amino acid targets of drug 65 GLN
52 GLY
127 GLY
No. of residues in known binding 17
Human similar targets 8
2 Superposition type L
RMSD 0.88 Å
Amino acid targets of drug 36 GLN
35 GLY
9 GLY
No. of residues in known binding 17
Human similar targets 8
Indinavir Known similar target molecule Polyprotein, HIV-1
Binding properties 1 1 Superposition type L
RMSD 0.94 Å
Amino acid targets of drug 78 ARG
107 PRO
108 VAL
No. of residues in known binding 24
Human similar targets 2
Lopinavir Known similar target molecule Protease, HIV-1
Binding properties 1 1 Superposition type L
RMSD 0.84 Å
Amino acid targets of drug 78 ARG
107 PRO
108 VAL
No. of residues in known binding 23
Human similar targets 6
Ritonavir Known similar target molecule Protease, HIV-1
Binding properties 1 1 Superposition type L
RMSD 1.12 Å
Amino acid targets of drug 78 ARG
107 PRO
108 VAL
No. of residues in known binding 23
Human similar targets 4
Saquinavir Known similar target molecule Protease, HIV-1
Binding properties 1 1 Superposition type L
RMSD 0.91 Å
Amino acid targets of drug 78 ARG
107 PRO
108 VAL
No. of residues in known binding 31
Human similar targets 8
  1. Features of different drug binding motifs. HIV-1 Human Immunodeficiency virus 1, RMSD Root Mean Square Deviation, Å angstrom, ILE isoleucine, GLY glycine, VAL valine, LEU leucine, PRO proline, ASP aspartic acid