Table 2 Antibacterial effect of antibiotics alone and in combination with increasing concentrations of sertraline (SR) against E. coli 87
From: Sertraline enhances the activity of antimicrobial agents against pathogens of clinical relevance
Antibiotic | Diameter of the inhibitory zone (mm) Mean ± SEM (n = 5) | ||||||
|---|---|---|---|---|---|---|---|
Control | Antibiotic + SR 10 μg ml -1 | Antibiotic + SR 20 μg ml -1 | Antibiotic + SR 40 μg ml -1 | Antibiotic + SR 60 μg ml -1 | Antibiotic + SR 80 μg ml -1 | Antibiotic + SR 100 μg ml -1 | |
Ciprofloxacin 5 μg | 20 ± 1.41 | 21 ± 00 | 23 ± 1.41* | 23.5 ± 0.70** | 30 ± 0.00*** | 33.5 ± 2.10*** | 39 ± 1.41*** |
Levofloxacin 5 μg | 18 ± 1.41 | 20 ± 0.50 | 21 ± 0.00 | 22 ± 0.50* | 25 ± 0.00** | 29 ± 0.00*** | 38 ± 1.41*** |
Norfloxacin 10 μg | 17 ± 0.41 | 17 ± 0.00 | 19.50 ± 2.12 | 25.50 ± 0.70* | 24.50 ± 0.70** | 27.50 ± 0.70*** | 35.50 ±0.70*** |
Moxifloxacin 5 μg | 20.5 ± 0.70 | 21 ± 0.12 | 22.50 ± 0.70 | 27.50 ± 0.70 | 27.50 ±0.70 | 32 ± 1.41*** | 40.50 ± 0.70*** |
Cefexime 5 μg | 0 ± 0.00 | 0 ± 0.00 | 0 ± 0.00 | 0 ± 0.00 | 0 ± 0.00 | 9.50 ± 0.70 | 13.50 ± 2.12 |
Cloxacillin 5 μg | 0 ± 0.00 | 0 ± 0.00 | 0 ± 0.00 | 0 ± 0.00 | 0 ± 0.00 | 0 ± 0.00 | 0 ± 0.00 |
Gentamicin 10 μg | 23 ± 2.82 | 24 ± 0.70 | 25 ± 2.82 | 29.5 ± 0.70* | 31.50 ± 0.70** | 34.50 ± 0.70** | 41.50 ± 0.70*** |