Fig. 2

The structure of AD1. a Alignment of AD1 in human E proteins (E2A, HEB, and E2-2). The blue shaded box denotes the core PCET motif, and the bottom symbols represent “*” identical residues, “:” conserved residues, and “.” semiconserved residues. The red dashed box represents the part of AD1 where the 3D structure has been reported. The LDFS motif is indicated by the red box. The amino acid sequences of human E proteins (E2A, HEB, and E2-2) were propagated from UniProtKB (P15923-2, Q99081-1, and P15884-1). b The 3D structure of a portion of E2A AD1 (residues 1–37). The 3D structure was derived from the Protein Data Bank (PDB: 2MH0); the blue helix denotes the PCET motif and is labeled; the two coils are shown in gray, and the short extended region is in blue