Fig. 5

Structure of the bHLH domain. a Sequence alignment of the bHLH domain of E47 from humans, rats, mice, Xenopus and chickens. Shaded boxes denote the amino acid sequence of each motif, “basic region, helix 1, loop, and helix 2”, and the bottom symbols represent “*” identical residues, “:” conserved residues, and “.” semiconserved residues. The amino acid sequences of the bHLH domain of E47 from humans, rats, mice, Xenopus and chickens were propagated from UniProtKB (P15923-2, P15806-2, P21677-2, Q70IK2-1, and Q01978-2, respectively). b The 3D structure of the bHLH domain of human E47. The area of each motif in the bHLH domain is displayed with the “basic region, helix 1, loop and helix 2”. The “basic region” is shown in blue, “helix 1” and “helix 2” are both shown in orange, and the “loop” is shown in dark blue. This 3D structure was obtained from the Protein Data Bank (PDB: 2YPB)